par Leo, Oberdan ;Foo, M;Sachs, D H;Samelson, L E;Bluestone, J A
Référence Proceedings of the National Academy of Sciences of the United States of America, 84, 5, page (1374-1378)
Publication Publié, 1987-03
Article révisé par les pairs
Résumé : A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-epsilon as a cell surface protein involved in the transduction of activation signals.