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Neuropeptide Y, somatostatin, and cholecystokinin neurone preservation in anaplastic astrocytomas.

par Przedborski, Serge ;Goldman, Serge ;Schiffmann, Serge N. ;Vierendeels, Godelieve ;Depierreux, Michel ;Levivier, Marc ;Hildebrand, Jerzy ;Vanderhaeghen, Jean-Jacques
Référence Acta Neuropathologica, 76, 5, page (507-510)
Publication Publié, 1988

Article révisé par les pairs

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Résumé :

Using immunohistochemistry, well-preserved neuronal cell bodies and fibres containing neuropeptide Y, somatostatin, and cholecystokinin immunoreactivity have been identified in all seven supratentorial anaplastic astrocytomas studied. These neurones have been shown not only on the edge but also in the depth of the neoplastic tissue. These neuropeptides were not present in 18 other intracranial tumours (3 astrocytomas, 1 subependymoma, 8 glioblastoma multiformes, 1 meningioma, and 5 metastases). In all 25 intracranial tumours studied, no immunoreactivity was found for vasoactive intestinal polypeptide, substance P, methionine-enkephalin, leucine-enkephalin, synenkephalin, neurophysin I-II, and corticotropin releasing factor.