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Leucémie à basophiles, évolution d'une leucémie myéloïde chronique. A propos d'un cas et revue de la littérature.

par Lossignol, Dominique ;Bron, Dominique ;Debusscher, L;Regnier, René ;Delforge, Alain ;Klastersky, Jean ;Stryckmans, Pierre
Référence Idees:Revista de temes contemporanis, 29, 5, page (307-310)
Publication Publié, 1987

Article révisé par les pairs

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Résumé :

Basophilic leukemia is a rare disease accounting for less than 2% of all hematopoietic malignancies and little is known about the best therapeutical approach. We report a case of basophilic leukemia occurring as an accelerated phase of chronic myelogenic leukemia in a 50 year old man with a past history of uranium and thorium exposure. He was successfully treated with intensive chemotherapy and total body irradiation followed by autologous peripheral stem cell transplantation. Such an approach has never been reported in this disease. However, the benefit on survival could not be evaluated because of a fatal opportunistic infection. The cases of basophilic leukemia reported in the literature are discussed.