Titre :
  • Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release.
Auteur : Hostens, K ; Pavlovic, D ; Zambre, Y ; Ling, Z ; Van Schravendijk, C. ; Eizirik, Decio L. ; Pipeleers, Daniel
Informations sur la publication : The Journal of clinical investigation, 104, 1, (page 67-72)
Statut de publication : Publié, 1999
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Adolescent
Adult
Apoptosis
Biological Markers
Cells, Cultured
Culture Media, Conditioned -- chemistry
Cytokines -- pharmacology
Cytokines -- toxicity
Diabetes Mellitus, Type 1 -- immunology
Diabetes Mellitus, Type 1 -- prevention & control
Drug Synergism
Humans
Hyperinsulinism -- chemically induced
Insulin -- secretion
Interferon-gamma -- pharmacology
Interferon-gamma -- toxicity
Interleukin-1 -- pharmacology
Interleukin-1 -- toxicity
Islets of Langerhans -- cytology
Islets of Langerhans -- drug effects
Islets of Langerhans -- immunology
Islets of Langerhans -- secretion
Middle Aged
Prediabetic State -- diagnosis
Prediabetic State -- physiopathology
Pro-Opiomelanocortin -- metabolism
Proinsulin -- biosynthesis
Proinsulin -- genetics
Proinsulin -- secretion
Proprotein Convertase 2
Reverse Transcriptase Polymerase Chain Reaction
Secretory Rate -- drug effects
Subtilisins -- metabolism
Tumor Necrosis Factor-alpha -- pharmacology
Tumor Necrosis Factor-alpha -- toxicity
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0021-9738 
info:doi/10.1172/JCI6438
info:pmid/10393700
info:pmcid/PMC408405