Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells.

Niemann, A; Björklund, A; Eizirik, Decio L.

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Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells.

par Niemann, A ;Björklund, A ;Eizirik, Decio L.

Référence Molecular and cellular endocrinology, 106, 1-2, page (151-155)
Publication Publié, 1994

Article révisé par les pairs

Résumé :

Nitric oxide, a radical generated by the enzyme nitric oxide synthase (iNOS), may be an important mediator of beta-cell damage in early insulin-dependent diabetes mellitus. We have investigated the molecular regulation of iNOS in insulin-producing RINm5F cells. The data obtained suggest that iNOS is maximally induced in these cells by a 6-h exposure to IL-1 beta or TNF-alpha + IFN-gamma, but not by endotoxin. iNOS mRNA degradation is rapid and it is not affected by IL-1 beta. Interestingly, NO seems to induce a negative feedback on iNOS expression, probably by decreasing iNOS transcription.

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