par Coune, André ;Sculier, Jean-Paul ;Fruhling, Janos ;Stryckmans, Pierre ;Brassinne, Christiane;Ghanem, Ghanem Elias ;Laduron, Chantal;Atassi, Ghanem ;Ruysschaert, Jean Marie ;Hildebrand, Jerzy
Référence Cancer treatment reports, 67, 11, page (1031-1033)
Publication Publié, 1983-11
Référence Cancer treatment reports, 67, 11, page (1031-1033)
Publication Publié, 1983-11
Article révisé par les pairs
Résumé : | Five patients with advanced multiresistant neoplasms were infused with NSC-251635 (a water-insoluble antimitotic agent) entrapped in egg yolk lecithin, cholesterol, and stearylamine liposomes. The maximum volume injected was 400 ml containing 8 g of lipids, ie, a dose of 135 mg/kg of body weight. Overall tolerance of the treatment was excellent. This study indicates that liposomes may be used safely as carriers for the iv administration of water-insoluble drugs to humans. |