par Schiffmann, Serge N. 
;Chéron, Guy ;Lohof, A.;D'Alcantara, Pablo ;Meyer, Matthias ;Parmentier, Marc ;Schurmans, Stéphane
Référence Proceedings of the National Academy of Sciences of the United States of America, 96, 9, page (5257-5262)
Publication Publié, 1999-04
;Chéron, Guy ;Lohof, A.;D'Alcantara, Pablo ;Meyer, Matthias ;Parmentier, Marc ;Schurmans, Stéphane Référence Proceedings of the National Academy of Sciences of the United States of America, 96, 9, page (5257-5262)
Publication Publié, 1999-04
Article révisé par les pairs
| Résumé : | In the cerebellum, the parallel fiber-Purkinje cell synapse can undergo long-term synaptic plasticity suggested to underlie motor learning and resulting from variations in intracellular calcium concentration ([Ca2+]i). Ca2+ binding proteins are enriched in the cerebellum, but their role in information processing is not clear. Here, we show that mice deficient in calretinin (Cr-/-) are impaired in tests of motor coordination. An impairment in Ca2+ homeostasis in Cr-/- Purkinje cells was supported by the high Ca2+-saturation of calbindin-D28k in these cells. The firing behavior of Purkinje cells is severely affected in Cr-/- alert mice, with alterations of simple spike firing rate, complex spike duration, and simple spike pause. In contrast, in slices, transmission at parallel fiber- or climbing fiber-Purkinje cell synapses is unaltered, indicating that marked modifications of the firing behavior in vivo can be undetectable in slice. Thus, these results show that calretinin plays a major role at the network level in cerebellar physiology. |
