par Langui, Dominique H.;Anderton, Brian;Brion, Jean Pierre ;Ulrich, J
Référence Brain research, 438, 1-2, page (67-76)
Publication Publié, 1988-01
Référence Brain research, 438, 1-2, page (67-76)
Publication Publié, 1988-01
Article révisé par les pairs
Résumé : | Neurofilamentous tangles have been induced by aluminium chloride in rat brain neurons cultivated on astroglial feeder layers. Monoclonal antibodies to neurofilaments were found to stain these aluminium-induced tangles. Immunostaining of these structures with anti-paired helical filament serum was always negative, though good staining of neuronal perikarya was achieved. This observation supports the hypothesis that aluminium-induced tangles are made up of neurofilament proteins. These tangles appear to be distinct immunochemically from Alzheimer-paired helical filaments. |