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Rapid improvement of bone metabolism after infliximab treatment in Crohn's disease.

par Franchimont, N;Putzeys, V;Collette, Jean Marie ;Vermeire, Séverine;Rutgeerts, Paul;De Vos, M;Van Gossum, André ;Franchimont, Denis ;Fiasse, René;Pelckmans, Paul;Malaisse, Willy ;Belaiche, Jacques;Louis, Edouard
Référence Alimentary pharmacology & therapeutics, 20, 6, page (607-614)
Publication Publié, 2004-09

Article révisé par les pairs

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Résumé :

BACKGROUND: Crohn's disease is associated with low bone mineral density and altered bone metabolism. AIM: To assess the evolution of bone metabolism in Crohn's disease patients treated with infliximab. METHODS: We studied 71 Crohn's disease patients treated for the first time with infliximab for refractory Crohn's disease. Biochemical markers of bone formation (type-I procollagen N-terminal propeptide, bone-specific alkaline phosphatase, osteocalcin) and of bone resorption (C-telopeptide of type-I collagen) were measured in the serum before and 8 weeks after infliximab therapy and compared with values in a matched healthy control group. RESULTS: Eight weeks after treatment with infliximab, a normalization of bone markers was observed with a median increase in formation markers of 14-51% according to marker and a lower but significant decrease in resorption marker (median 11%). A clinically relevant increase in bone formation markers was present in 30-61% of patients according to the marker. A clinically relevant decrease in C-telopeptide of type-I collagen was present in 38% of patients. No association was found with any tested demographic or clinical parameter. CONCLUSION: Infliximab therapy in Crohn's disease may rapidly influence bone metabolism by acting either on bone formation or bone resorption. This improvement seems to be independent of clinical response to infliximab.