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Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha.

par Franchimont, Denis ;Galon, J;Vacchio, M.;Fan, S.;Visconti, R;Frucht, D M;Chrousos, G P;Ashwell, J.D.;O'Shea, J J
Référence The Journal of immunology, 168, 5, page (2212-2218)
Publication Publié, 2002-03

Article révisé par les pairs

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Résumé :

Despite the effects of glucocorticoids on immune function, relatively little is known about glucocorticoid-inducible genes and how their products may regulate lymphocyte function. Using DNA microarray technology to analyze gene expression in PBMC from healthy donors, we identified IL-7Ralpha as a glucocorticoid-inducible gene. This observation was confirmed at the mRNA and protein levels. Conversely, TCR signaling decreased IL-7Ralpha expression, and the relative strength of signaling between these two receptors determined the final IL-7Ralpha levels. The up-regulation of IL-7Ralpha by glucocorticoids was associated with enhanced IL-7-mediated signaling and function. Moreover, IL-7-mediated inhibition of apoptosis at increasing concentrations of glucocorticoids is consistent with enhanced cell sensitivity to IL-7 following glucocorticoid exposure. These observations provide a mechanism by which glucocorticoids may have a positive influence on T cell survival and function.