Titre :
  • Phosphorylated HER-2 tyrosine kinase and Her-2/neu gene amplification as predictive factors of response to trastuzumab in patients with HER-2 overexpressing metastatic breast cancer (MBC).
Auteur : Giuliani, Rosa ; Durbecq, Virginie ; Di Leo, Angelo ; Paesmans, Marianne ; Larsimont, Denis ; Leroy, Jean-Yves ; Borms, Marleen ; Vindevoghel, Anita ; Jerusalem, Guy ; D'Hondt, Véronique ; Dirix, Luc Y ; Canon, Jean-Luc ; Richard, Vincent ; Cocquyt, Veronique ; Majois, Françoise ; Reginster, Michel ; Demol, Jan ; Kains, Jean-Pierre ; Delree, Paul ; Keppens, Carine ; Sotiriou, Christos ; Piccart-Gebhart, Martine ; Cardoso, Fatima
Informations sur la publication : European journal of cancer, 43, 4, (page 725-735)
Statut de publication : Publié, 2007-03
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Metastatic breast cancer
Phosphorylated HER-2
Predictive factors
Trastuzumab
Mots-clés MeSH : Antibodies, Monoclonal -- therapeutic use
Antineoplastic Agents -- therapeutic use
Breast Neoplasms -- drug therapy
Breast Neoplasms -- genetics
Female
Gene Amplification
Genes, erbB-2 -- genetics
Humans
In Situ Hybridization, Fluorescence
Neoplasm Metastasis
Phosphorylation
Protein-Tyrosine Kinases -- genetics
Protein-Tyrosine Kinases -- metabolism
Receptor, erbB-2 -- metabolism
Retrospective Studies
Treatment Outcome
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0959-8049 
info:doi/10.1016/j.ejca.2006.11.019
info:pii/S0959-8049(06)01065-3
info:pmid/17251007