Article révisé par les pairs
Titre :
  • Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice.
Auteur : Nayeem, Mohammed A ; Poloyac, Samuel M ; Falck, John R ; Zeldin, Darryl C ; Ledent, Catherine ; Ponnoth, Dovenia S ; Ansari, H R ; Mustafa, S Jamal
Informations sur la publication : American journal of physiology. Heart and circulatory physiology, 295, 5, (page H2068-H2078)
Statut de publication : Publié, 2008-11
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Adenosine
Cytochrome P-450s
Dihydroxyeicosatrienoic acids
Epoxyeicosatrienoic acids
Vasoconstriction
Vasodilation
Mots-clés MeSH : 8,11,14-Eicosatrienoic Acid -- analogs & derivatives
8,11,14-Eicosatrienoic Acid -- pharmacology
Acetylcholine -- pharmacology
Adenosine -- analogs & derivatives
Adenosine -- pharmacology
Adenosine-5'-(N-ethylcarboxamide) -- pharmacology
Alkane 1-Monooxygenase -- antagonists & inhibitors
Alkane 1-Monooxygenase -- metabolism
Amides -- pharmacology
Amidines -- pharmacology
Animals
Aorta -- drug effects
Aorta -- enzymology
Arachidonic Acid -- metabolism
Chromatography, Liquid
Cytochrome P-450 Enzyme System -- antagonists & inhibitors
Cytochrome P-450 Enzyme System -- metabolism
Dose-Response Relationship, Drug
Enzyme Inhibitors -- pharmacology
Indomethacin -- pharmacology
Male
Mice
Mice, Knockout
NG-Nitroarginine Methyl Ester -- pharmacology
Nitric Oxide Synthase -- antagonists & inhibitors
Nitric Oxide Synthase -- metabolism
Phenethylamines -- pharmacology
Prostaglandin-Endoperoxide Synthases -- metabolism
Pyrimidines -- pharmacology
Receptor, Adenosine A2A -- deficiency
Receptor, Adenosine A2A -- genetics
Receptor, Adenosine A2A -- metabolism
Tandem Mass Spectrometry
Triazoles -- pharmacology
Vasoconstriction -- drug effects
Vasoconstrictor Agents -- pharmacology
Vasodilation -- drug effects
Vasodilator Agents -- pharmacology
Note : Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langue :
  • Anglais
Identificateurs : urn:issn:0363-6135 
info:doi/10.1152/ajpheart.01333.2007
info:pii/01333.2007
info:pmid/18805895
info:pmcid/PMC2614586