Titre :
  • Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients.
Auteur : Bulitta, Jürgen B ; Zhao, Ping ; Arnold, Robert D ; Kessler, Dean R ; Daifuku, Richard ; Pratt, James ; Luciano, Gabriel ; Hanauske, Axel-R ; Gelderblom, Hans ; Awada, Ahmad ; Jusko, William J
Informations sur la publication : Cancer chemotherapy and pharmacology, 63, 6, (page 1049-1063)
Statut de publication : Publié, 2009-05
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Mechanistic modeling
Non-hematological malignancies
NONMEM
Paclitaxel
Population pharmacokinetics
Solubility limited disposition model
Ultrafiltration
Mots-clés MeSH : Adult
Antineoplastic Agents, Phytogenic -- administration & dosage
Antineoplastic Agents, Phytogenic -- blood
Antineoplastic Agents, Phytogenic -- chemistry
Antineoplastic Agents, Phytogenic -- pharmacokinetics
Antineoplastic Agents, Phytogenic -- therapeutic use
Chemistry, Pharmaceutical
Chromatography, Liquid
Cross-Over Studies
Drug Delivery Systems -- methods
Female
Humans
Leukocyte Count
Linear Models
Male
Middle Aged
Models, Biological
Monte Carlo Method
Nanoparticles
Neoplasms -- drug therapy
Paclitaxel -- administration & dosage
Paclitaxel -- blood
Paclitaxel -- chemistry
Paclitaxel -- pharmacokinetics
Paclitaxel -- therapeutic use
Structure-Activity Relationship
Tandem Mass Spectrometry
Tissue Distribution
Note : Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0344-5704 
info:doi/10.1007/s00280-008-0827-2
info:pmid/18791718