Titre :
  • The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: results of a phase I study with pharmacokinetics.
Auteur : Awada, Ahmad ; Cardoso, Fatima ; Fontaine, C. ; Dirix, Luc Y ; De Greve, Jacques ; Sotiriou, Christos ; Steinseifer, Jutta ; Wouters, Carine ; Tanaka, Chiaki ; Zoellner, Ulrike ; Tang, Pui ; Piccart-Gebhart, Martine
Informations sur la publication : European journal of cancer, 44, 1, (page 84-91)
Statut de publication : Publié, 2008-01
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Breast cancer
Everolimus
Letrozole
mTOR
Pharmacokinetics
Phase I
RAD001
Mots-clés MeSH : Administration, Oral
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols -- adverse effects
Antineoplastic Combined Chemotherapy Protocols -- pharmacokinetics
Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
Breast Neoplasms -- drug therapy
Cohort Studies
Drug Interactions
Feasibility Studies
Female
Humans
Immunosuppressive Agents -- administration & dosage
Immunosuppressive Agents -- adverse effects
Immunosuppressive Agents -- pharmacokinetics
Male
Middle Aged
Nitriles -- administration & dosage
Nitriles -- adverse effects
Nitriles -- pharmacokinetics
Sirolimus -- administration & dosage
Sirolimus -- adverse effects
Sirolimus -- analogs & derivatives
Sirolimus -- pharmacokinetics
Treatment Outcome
Triazoles -- administration & dosage
Triazoles -- adverse effects
Triazoles -- pharmacokinetics
Note : Clinical Trial, Phase I
Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0959-8049 
info:doi/10.1016/j.ejca.2007.10.003
info:pii/S0959-8049(07)00793-9
info:pmid/18039566