Titre :
  • Pharmacokinetics of tipifarnib after oral and intravenous administration in subjects with advanced cancer.
Auteur : Zhang, Steven ; Zannikos, Peter ; Awada, Ahmad ; Piccart-Gebhart, Martine ; Dirix, Luc Y ; Fumoleau, Pierre ; Verhaeghe, Tom ; Francois, Marc ; De Porre, Peter
Informations sur la publication : Journal of clinical pharmacology, 46, 10, (page 1116-1127)
Statut de publication : Publié, 2006-10
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Intravenous infusion
Metabolite
Oral administration
Pharmacokinetics
Protein binding
Tipifarnib
Mots-clés MeSH : Administration, Oral
Adult
Aged
Area Under Curve
Biological Availability
Dose-Response Relationship, Drug
Drug Administration Schedule
Enzyme Inhibitors -- administration & dosage
Enzyme Inhibitors -- pharmacokinetics
Farnesyltranstransferase -- antagonists & inhibitors
Female
Glucuronides -- metabolism
Glycoproteins -- metabolism
Humans
Infusions, Intravenous
Male
Metabolic Clearance Rate
Middle Aged
Neoplasms -- drug therapy
Neoplasms -- metabolism
Protein Binding
Quinolones -- metabolism
Quinolones -- pharmacokinetics
Quinolones -- therapeutic use
Serum Albumin -- metabolism
Tablets
Treatment Outcome
Note : Journal Article
Randomized Controlled Trial
FLWIN
Langue :
  • Anglais
Identificateurs : urn:issn:0091-2700 
info:doi/10.1177/0091270006291034
info:pii/46/10/1116
info:pmid/16988200