Titre :
  • A phase I clinical and pharmacokinetic study of tipifarnib in combination with docetaxel in patients with advanced solid malignancies.
Auteur : Awada, Ahmad ; Zhang, Steven ; Gil, Thierry ; De Valeriola, Dominique ; Lalami, Yassine ; De Porre, Peter ; Piccart-Gebhart, Martine
Informations sur la publication : Current medical research and opinion, 23, 5, (page 991-1003)
Statut de publication : Publié, 2007-05
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Docetaxel
Farnesyltransferase inhibitor
Pharmacokinetics
Phase I
Solid cancer
Tipifarnib
Mots-clés MeSH : Adult
Aged
Antineoplastic Combined Chemotherapy Protocols -- adverse effects
Antineoplastic Combined Chemotherapy Protocols -- pharmacokinetics
Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
Breast Neoplasms -- drug therapy
Breast Neoplasms -- pathology
Dose-Response Relationship, Drug
Drug Administration Routes
Drug Administration Schedule
Drug Interactions
Female
Humans
Immune System -- drug effects
Male
Maximum Tolerated Dose
Middle Aged
Neoplasms -- drug therapy
Neoplasms -- pathology
Quinolones -- administration & dosage
Quinolones -- adverse effects
Quinolones -- pharmacokinetics
Taxoids -- administration & dosage
Taxoids -- adverse effects
Taxoids -- pharmacokinetics
Treatment Outcome
Note : Clinical Trial, Phase I
Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0300-7995 
info:doi/10.1185/030079907X178810
info:pmid/17519066