Hypoxia-inducible factor in cancer angiogenesis: structure, regulation and clinical perspectives.

Otrock, Zaher K; Hatoum, Hassan A; Awada, Ahmad; Ishak, Rim S; Shamseddine, Ali I

doi:doi/10.1016/j.critrevonc.2009.01.001

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Hypoxia-inducible factor in cancer angiogenesis: structure, regulation and clinical perspectives.

par Otrock, Zaher K ;Hatoum, Hassan A ;Awada, Ahmad

;Ishak, Rim S ;Shamseddine, Ali I
Référence Critical reviews in oncology/hematology, 70, 2, page (93-102)
Publication Publié, 2009-05

Article révisé par les pairs

Résumé :

Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this paper, we review what has been described about HIF-1: its structure, its regulation and target genes, its role in cancer, and its implication for cancer therapy.

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