Titre :
  • Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.
Auteur : Sebille, Sophie ; Gall, David ; de Tullio, Pascal ; Florence, Xavier ; Lebrun, Philippe ; Pirotte, Bernard
Informations sur la publication : Journal of medicinal chemistry, 49, 15, (page 4690-4697)
Statut de publication : Publié, 2006-07
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Adenosine Triphosphate -- physiology
Animals
Aorta, Thoracic -- drug effects
Aorta, Thoracic -- physiology
Benzopyrans -- chemical synthesis
Benzopyrans -- chemistry
Benzopyrans -- pharmacology
Cromakalim -- chemistry
Insulin -- secretion
Insulin-Secreting Cells -- drug effects
Insulin-Secreting Cells -- physiology
Insulin-Secreting Cells -- secretion
Ion Channel Gating -- drug effects
Muscle Contraction
Muscle, Smooth, Vascular -- drug effects
Muscle, Smooth, Vascular -- physiology
Patch-Clamp Techniques
Phenylurea Compounds -- chemical synthesis
Phenylurea Compounds -- chemistry
Phenylurea Compounds -- pharmacology
Potassium Channels -- drug effects
Rats
Rats, Wistar
Stereoisomerism
Structure-Activity Relationship
Note : In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0022-2623 
info:doi/10.1021/jm060161z
info:pmid/16854075