Titre:
  • The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) induces apoptosis, downregulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells.
Auteur:Stamatopoulos, Basile; Meuleman, Nathalie; De Bruyn, Cécile; Delforge, Alain; Bron, Dominique; Lagneaux, Laurence
Informations sur la publication:Haematologica, 95, 7, page (1136-1143)
Statut de publication:Publié, 2010-02
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Chronic lymphocytic leukemia
CXCR4
Migration
Suberoylanilide hydroxamic acid
MeSH keywords:Antineoplastic Agents
Apoptosis -- drug effects
Cell Movement -- drug effects
Down-Regulation -- drug effects
Histone Deacetylase Inhibitors -- therapeutic use
Humans
Hydroxamic Acids -- pharmacology
Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy -- pathology
Receptors, CXCR4 -- antagonists & inhibitors
Tumor Cells, Cultured
Note générale:JOURNAL ARTICLE
SCOPUS: ar.j
Langue:Autre
Identificateurs:urn:issn:0390-6078
info:doi/10.3324/haematol.2009.013847
info:pii/haematol.2009.013847
info:scp/77953749866
info:pmid/20145270