Titre :
  • The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) induces apoptosis, downregulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells.
Auteur : Stamatopoulos, Basile ; Meuleman, Nathalie ; De Bruyn, Cécile ; Delforge, Alain ; Bron, Dominique ; Lagneaux, Laurence
Informations sur la publication : Haematologica, 95, 7, (page 1136-1143)
Statut de publication : Publié, 2010-02
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Chronic lymphocytic leukemia
CXCR4
Migration
Suberoylanilide hydroxamic acid
Mots-clés MeSH : Antineoplastic Agents
Apoptosis -- drug effects
Cell Movement -- drug effects
Down-Regulation -- drug effects
Histone Deacetylase Inhibitors -- therapeutic use
Humans
Hydroxamic Acids -- pharmacology
Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy -- pathology
Receptors, CXCR4 -- antagonists & inhibitors
Tumor Cells, Cultured
Note : JOURNAL ARTICLE
SCOPUS: ar.j
Langue :
Identificateurs : urn:issn:0390-6078 
info:doi/10.3324/haematol.2009.013847
info:pii/haematol.2009.013847
info:pmid/20145270