Titre:
  • Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.
Auteur:Ortis, Fernanda; Pirot, Pierre; Naamane, Najib; Kreins, A Y; Rasschaert, Joanne; Moore, F; Théâtre, E; Verhaeghe, C; Magnusson, N E; Chariot, Alain; Orntoft, Torben Falck; Eizirik, Decio L.
Informations sur la publication:Diabetologia, 51, 7, page (1213-1225)
Statut de publication:Publié, 2008
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Apoptosis
Diabetes mellitus
IL-1β
NF-κB
Pancreatic beta cells
TNF-α
MeSH keywords:Animals
Apoptosis -- drug effects
Apoptosis -- physiology
Cell Nucleus -- metabolism
Cells, Cultured
Diabetes Mellitus, Type 1 -- immunology
Diabetes Mellitus, Type 1 -- pathology
Diabetes Mellitus, Type 1 -- physiopathology
Gene Expression Profiling
Gene Expression Regulation -- drug effects
Gene Expression Regulation -- immunology
I-kappa B Kinase -- metabolism
Insulin-Secreting Cells -- cytology
Insulin-Secreting Cells -- drug effects
Insulin-Secreting Cells -- physiology
Interleukin-1beta -- metabolism
Interleukin-1beta -- pharmacology
NF-kappa B -- genetics
NF-kappa B -- metabolism
Oligonucleotide Array Sequence Analysis
Rats
Rats, Wistar
Signal Transduction -- drug effects
Signal Transduction -- immunology
Tumor Necrosis Factor-alpha -- metabolism
Tumor Necrosis Factor-alpha -- pharmacology
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0012-186X
info:doi/10.1007/s00125-008-0999-7
info:scp/44749083828
info:pmid/18463842