Titre :
  • Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.
Auteur : Ortis, Fernanda ; Pirot, Pierre ; Naamane, Najib ; Kreins, A Y ; Rasschaert, Joanne ; Moore, F ; Théâtre, E ; Verhaeghe, C ; Magnusson, N E ; Chariot, Alain ; Orntoft, Torben Falck ; Eizirik, Decio L.
Informations sur la publication : Diabetologia, 51, 7, (page 1213-1225)
Statut de publication : Publié, 2008
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Apoptosis
Diabetes mellitus
IL-1β
NF-κB
Pancreatic beta cells
TNF-α
Mots-clés MeSH : Animals
Apoptosis -- drug effects
Apoptosis -- physiology
Cell Nucleus -- metabolism
Cells, Cultured
Diabetes Mellitus, Type 1 -- immunology
Diabetes Mellitus, Type 1 -- pathology
Diabetes Mellitus, Type 1 -- physiopathology
Gene Expression Profiling
Gene Expression Regulation -- drug effects
Gene Expression Regulation -- immunology
I-kappa B Kinase -- metabolism
Insulin-Secreting Cells -- cytology
Insulin-Secreting Cells -- drug effects
Insulin-Secreting Cells -- physiology
Interleukin-1beta -- metabolism
Interleukin-1beta -- pharmacology
NF-kappa B -- genetics
NF-kappa B -- metabolism
Oligonucleotide Array Sequence Analysis
Rats
Rats, Wistar
Signal Transduction -- drug effects
Signal Transduction -- immunology
Tumor Necrosis Factor-alpha -- metabolism
Tumor Necrosis Factor-alpha -- pharmacology
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0012-186X 
info:doi/10.1007/s00125-008-0999-7
info:pmid/18463842