Titre :
  • Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Auteur : Karlsen, A E ; Heding, P E ; Frobøse, H ; Rønn, S G ; Kruhøffer, Mogens ; Orntoft, Torben Falck ; Darville, Martine ; Eizirik, Decio L. ; Pociot, Flemming ; Nerup, J ; Mandrup-Poulsen, T. ; Billestrup, N
Informations sur la publication : Diabetologia, 47, 11, (page 1998-2011)
Statut de publication : Publié, 2004
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Autoimmunity
Beta cells
Cell signalling
Cytokines
IL-1β
Nitric oxide synthase
Mots-clés MeSH : Animals
Apoptosis -- drug effects
Base Sequence
Cell Line
DNA Primers
Gene Expression Regulation
Interleukin-1 -- toxicity
NF-kappa B -- physiology
Nitric Oxide -- metabolism
Oligonucleotide Array Sequence Analysis
Rats
Repressor Proteins -- genetics
Repressor Proteins -- physiology
Signal Transduction -- drug effects
Signal Transduction -- physiology
Suppressor of Cytokine Signaling Proteins
Transcription Factors -- genetics
Transcription Factors -- physiology
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0012-186X 
info:doi/10.1007/s00125-004-1568-3
info:pmid/15578154