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Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.

par Karlsen, A E;Heding, P E;Frobøse, H;Rønn, S G;Kruhøffer, Mogens;Orntoft, Torben Falck;Darville, Martine ;Eizirik, Decio L. ;Pociot, Flemming;Nerup, J;Mandrup-Poulsen, T.;Billestrup, N
Référence Diabetologia, 47, 11, page (1998-2011)
Publication Publié, 2004

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Titre:	Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Auteur:	Karlsen, A E; Heding, P E; Frobøse, H; Rønn, S G; Kruhøffer, Mogens; Orntoft, Torben Falck; Darville, Martine; Eizirik, Decio L.; Pociot, Flemming; Nerup, J; Mandrup-Poulsen, T.; Billestrup, N
Informations sur la publication:	Diabetologia, 47, 11, page (1998-2011)
Statut de publication:	Publié, 2004
Sujet CREF:	Sciences bio-médicales et agricoles
Mots-clés:	Autoimmunity
	Beta cells
	Cell signalling
	Cytokines
	IL-1β
	Nitric oxide synthase
MeSH keywords:	Animals
	Apoptosis -- drug effects
	Base Sequence
	Cell Line
	DNA Primers
	Gene Expression Regulation
	Interleukin-1 -- toxicity
	NF-kappa B -- physiology
	Nitric Oxide -- metabolism
	Oligonucleotide Array Sequence Analysis
	Rats
	Repressor Proteins -- genetics
	Repressor Proteins -- physiology
	Signal Transduction -- drug effects
	Signal Transduction -- physiology
	Suppressor of Cytokine Signaling Proteins
	Transcription Factors -- genetics
	Transcription Factors -- physiology
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0012-186X
	info:doi/10.1007/s00125-004-1568-3
	info:scp/19944429062
	info:pmid/15578154