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Cytotoxic pentacyclic triterpenes from Combretum nigricans.

par Simon, Gentiane;Dewelle, Janique;Nacoulma, Odile;Guissou, Pierre;Kiss, Robert ;Daloze, Désiré ;Braekman, Jean Claude
Référence Fitoterapia, 74, 4, page (339-344)
Publication Publié, 2003-06

Article révisé par les pairs

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Résumé :

A new pentacyclic triterpene, 11alpha-acetoxy-20,24-epoxy-25-hydroxy-dammar-3-one (1), has been isolated from the African tree Combretum nigricans, together with the known corresponding diol, 20,24-epoxy-11alpha, 25-dihydroxy-dammar-3-one (2). They are responsible, at least in part, for the cytotoxic activity of the methanolic extract of the plant.