Titre :
  • Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resistance protein, prostaglandin E synthetase, and glutathione-S-transferase-alpha (GST)-alpha, GST-mu, and GST-pi.
Auteur : Mathieu, Anne ; Remmelink, Myriam ; D'Haene, Nicky ; Penant, Stanislas ; Gaussin, Jean-François ; Van Ginckel, Rob ; Darro, Francis ; Kiss, Robert ; Salmon, Isabelle
Informations sur la publication : Cancer, 101, 8, (page 1908-1918)
Statut de publication : Publié, 2004-10
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Chemoresistance
Cyclooxygenase-2
Glutathione-S-transferase
Lung-related resistance protein
Nonsmall cell lung carcinoma
NS-398
Ornithine decarboxylase
Orthotopic model
Prostaglandin E synthetase
Mots-clés MeSH : Animals
Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
Brain Neoplasms -- drug therapy
Brain Neoplasms -- metabolism
Brain Neoplasms -- secondary
Camptothecin -- administration & dosage
Camptothecin -- analogs & derivatives
Carcinoma, Non-Small-Cell Lung -- drug therapy
Carcinoma, Non-Small-Cell Lung -- metabolism
Carcinoma, Non-Small-Cell Lung -- pathology
Cyclooxygenase 2
Disease Models, Animal
Drug Resistance, Neoplasm
Female
Glutathione S-Transferase pi
Glutathione Transferase -- metabolism
Humans
Intramolecular Oxidoreductases -- metabolism
Isoenzymes -- metabolism
Liver Neoplasms -- drug therapy
Liver Neoplasms -- metabolism
Liver Neoplasms -- secondary
Lung Neoplasms -- drug therapy
Lung Neoplasms -- metabolism
Lung Neoplasms -- pathology
Membrane Proteins
Mice
Mice, Nude
Neoplasm Proteins -- metabolism
Organoplatinum Compounds -- administration & dosage
Ornithine Decarboxylase -- metabolism
Paclitaxel -- administration & dosage
Prostaglandin-Endoperoxide Synthases -- metabolism
Survival Rate
Transplantation, Heterologous
Tumor Markers, Biological -- metabolism
Vault Ribonucleoprotein Particles -- metabolism
Note : Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
FLWIN
Langue :
  • Anglais
Identificateurs : urn:issn:0008-543X 
info:doi/10.1002/cncr.20571
info:pmid/15386340