Titre :
  • Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.
Auteur : Van Quaquebeke, Eric ; Simon, Gentiane ; André, Aurélie ; Dewelle, Janique ; El Yazidi, Mohamed ; Bruyneel, Frederic ; Tuti, Jérôme ; Nacoulma, Odile ; Guissou, Pierre ; Decaestecker, Christine ; Braekman, Jean Claude ; Kiss, Robert ; Darro, Francis
Informations sur la publication : Journal of medicinal chemistry, 48, 3, (page 849-856)
Statut de publication : Publié, 2005-02
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Animals
Antineoplastic Agents -- chemical synthesis
Antineoplastic Agents -- isolation & purification
Antineoplastic Agents -- pharmacology
Calotropis -- chemistry
Camptothecin -- analogs & derivatives
Camptothecin -- pharmacology
Cardenolides -- chemical synthesis
Cardenolides -- isolation & purification
Cardenolides -- pharmacology
Cell Line, Tumor
Cell Proliferation -- drug effects
Cerebral Cortex -- chemistry
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Etoposide -- pharmacology
Humans
Magnetic Resonance Spectroscopy
Maximum Tolerated Dose
Mice
Organoplatinum Compounds -- pharmacology
Paclitaxel -- pharmacology
Sodium-Potassium-Exchanging ATPase -- chemistry
Structure-Activity Relationship
Swine
Thiazoles -- chemical synthesis
Thiazoles -- isolation & purification
Thiazoles -- pharmacology
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0022-2623 
info:doi/10.1021/jm049405a
info:pmid/15689169