Titre:
  • Cardenolide-induced lysosomal membrane permeabilization demonstrates therapeutic benefits in experimental human non-small cell lung cancers.
Auteur:Mijatovic, Tatjana; Mathieu, Véronique; Gaussin, Jean-François; De Nève, Nancy; Ribaucour, Fabrice; Van Quaquebeke, Eric; Dumont, Patrick; Darro, Francis; Kiss, Robert
Informations sur la publication:Neoplasia (New York, N.Y.), 8, 5, page (402-412)
Statut de publication:Publié, 2006-05
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Antitumor agent
Cardenolides
Hsp70
Lysosomal membrane permeabilization
NSCLCs
MeSH keywords:Acridine Orange -- pharmacology
Animals
Antineoplastic Agents -- pharmacology
Carcinoma, Non-Small-Cell Lung -- drug therapy
Cardenolides -- pharmacology
Cathepsin B -- metabolism
Cell Line, Tumor
Disease Models, Animal
Female
Gene Expression Regulation, Neoplastic
HSP70 Heat-Shock Proteins -- metabolism
Humans
Lung Neoplasms -- drug therapy
Lysosomes -- chemistry
Mice
Mice, Nude
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:1476-5586
info:doi/10.1593/neo.05850
info:scp/33744824903
info:pmid/16790089
PMC1592454