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Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines.

par Rives, Arnaud;Le Calve, Benjamin ;Delaine, Tamara;Legentil, Laurent;Kiss, Robert ;Delfourne, Evelyne
Référence European journal of medicinal chemistry, 45, 1, page (343-351)
Publication Publié, 2010-01

Article révisé par les pairs

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Résumé :

Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.