Titre:
  • New pyridinone derivatives as potent HIV-1 nonnucleoside reverse transcriptase inhibitors.
Auteur:Le Van, Kiet; Cauvin, Christine; De Walque, Stéphane; Georges, Benoît; Boland, Sandro; Martinelli, Valérie; Demonte, Dominique; Durant, François; Hevesi, László; Van Lint, Carine
Informations sur la publication:Journal of medicinal chemistry, 52, 12, page (3636-3643)
Statut de publication:Publié, 2009
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Anti-HIV Agents -- chemical synthesis
Anti-HIV Agents -- chemistry
Anti-HIV Agents -- pharmacology
Binding Sites
Cell Line
Cell Survival -- drug effects
Cell Transformation, Viral -- drug effects
Computer Simulation
Crystallography, X-Ray
HIV -- drug effects
HIV Reverse Transcriptase -- antagonists & inhibitors
Humans
Microbial Sensitivity Tests
Models, Chemical
Models, Molecular
Molecular Structure
Pyridones -- chemical synthesis
Pyridones -- chemistry
Pyridones -- pharmacology
Reverse Transcriptase Inhibitors -- chemical synthesis
Reverse Transcriptase Inhibitors -- chemistry
Reverse Transcriptase Inhibitors -- pharmacology
Stereoisomerism
Structure-Activity Relationship
Note générale:Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0022-2623
info:doi/10.1021/jm801438e
info:scp/67549128954
info:pmid/19469474