Titre :
  • The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin.
Auteur : Springael, Jean-Yves ; De Poorter, Cédric ; Deupi, Xavier ; Van Durme, Joost ; Pardo, Leonardo ; Parmentier, Marc
Informations sur la publication : Cellular signalling, 19, 7, (page 1446-1456)
Statut de publication : Publié, 2007-07
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Activation
CCR5
Constitutive activity
Mots-clés MeSH : Amino Acid Sequence
Animals
CHO Cells
Cattle
Chemokine CCL4
Computational Biology
Cricetinae
Cricetulus
Down-Regulation -- drug effects
Down-Regulation -- genetics
Endocytosis -- drug effects
Enzyme Activation -- drug effects
Kinetics
Ligands
Macrophage Inflammatory Proteins -- pharmacology
Mitogen-Activated Protein Kinases -- metabolism
Molecular Sequence Data
Mutant Proteins -- genetics
Mutant Proteins -- metabolism
Protein Structure, Quaternary
Protein Structure, Secondary
Protein Structure, Tertiary
Receptors, CCR5 -- chemistry
Receptors, CCR5 -- metabolism
Rhodopsin -- chemistry
Rhodopsin -- metabolism
Structure-Activity Relationship
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0898-6568 
info:doi/10.1016/j.cellsig.2007.01.022
info:pii/S0898-6568(07)00036-8
info:pmid/17320349