Titre :
  • Highly potent HIV inhibition: engineering a key anti-HIV structure from PSC-RANTES into MIP-1 beta/CCL4.
Auteur : Gaertner, Hubert ; Lebeau, Olivier ; Borlat, Irène ; Cerini, Fabrice ; Dufour, Brigitte ; Kuenzi, Gabriel ; Melotti, Astrid ; Fish, Richard J ; Offord, Robin ; Springael, Jean-Yves ; Parmentier, Marc ; Hartley, Oliver
Informations sur la publication : Protein engineering, design & selection, 21, 2, (page 65-72)
Statut de publication : Publié, 2008-02
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : CCR5
HIV coreceptor
MIP-1β CCL4
Pharmacophore grafting
PSC-RANTES
Mots-clés MeSH : Amino Acid Sequence
Anti-HIV Agents -- chemical synthesis
Cells, Cultured
Chemokine CCL4 -- genetics
Chemokine CCL4 -- therapeutic use
Chemokine CCL5 -- genetics
Chemokine CCL5 -- therapeutic use
Drug Design
HIV -- drug effects
Humans
Molecular Sequence Data
Structure-Activity Relationship
Note : Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:1741-0126 
info:doi/10.1093/protein/gzm079
info:pii/gzm079
info:pmid/18178567