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To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front.

par Van Keymeulen, Alexandra ;Wong, Kit;Knight, Zachary A;Govaerts, Cédric ;Hahn, Klaus M;Shokat, Kevan M;Bourne, Henry R
Référence The Journal of cell biology, 174, 3, page (437-445)
Publication Publié, 2006-07

Article révisé par les pairs

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Titre:	To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front.
Auteur:	Van Keymeulen, Alexandra; Wong, Kit; Knight, Zachary A; Govaerts, Cédric; Hahn, Klaus M; Shokat, Kevan M; Bourne, Henry R
Informations sur la publication:	The Journal of cell biology, 174, 3, page (437-445)
Statut de publication:	Publié, 2006-07
Sujet CREF:	Sciences bio-médicales et agricoles
	Biochimie
	Biologie
	Biologie cellulaire
	Biologie moléculaire
	Biophysique
	Sciences biomédicales
	Sciences de la matière vivante
MeSH keywords:	1-Phosphatidylinositol 3-Kinase -- antagonists & inhibitors
	Bicyclo Compounds, Heterocyclic -- pharmacology
	Cell Differentiation -- drug effects
	Cell Polarity -- drug effects
	Cells, Cultured
	Chemotaxis, Leukocyte -- drug effects
	HL-60 Cells
	Humans
	N-Formylmethionine Leucyl-Phenylalanine -- pharmacology
	Neutrophils -- cytology
	Phenotype
	Phosphatidylinositol Phosphates -- metabolism
	Phosphorylation -- drug effects
	Protein Transport -- drug effects
	Pseudopodia -- drug effects
	Signal Transduction
	Thiazoles -- pharmacology
	Thiazolidines
	cdc42 GTP-Binding Protein -- metabolism
	rhoA GTP-Binding Protein -- metabolism
Note générale:	Journal Article
	Research Support, N.I.H., Extramural
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0021-9525
	info:doi/10.1083/jcb.200604113
	info:pii/jcb.200604113
	info:pmid/16864657