Titre :
  • Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
Auteur : Lepesheva, Galina I ; Park, Hee-Won ; Hargrove, Tatiana Y ; Vanhollebeke, Benoît ; Wawrzak, Zdzislaw ; Harp, Joel M ; Sundaramoorthy, Munirathinam ; Nes, W David ; Pays, Etienne ; Chaudhuri, Minu ; Villalta, Fernando ; Waterman, Michael R
Informations sur la publication : The Journal of biological chemistry, 285, 3, (page 1773-1780)
Statut de publication : Publié, 2010-01
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Amino Acid Sequence
Benzamides -- chemistry
Benzamides -- metabolism
Benzamides -- pharmacology
Benzamides -- therapeutic use
Biocatalysis
Crystallography, X-Ray
Cytochrome P-450 Enzyme System -- antagonists & inhibitors
Cytochrome P-450 Enzyme System -- chemistry
Cytochrome P-450 Enzyme System -- metabolism
Drug Design
Enzyme Inhibitors -- chemistry
Enzyme Inhibitors -- metabolism
Enzyme Inhibitors -- pharmacology
Enzyme Inhibitors -- therapeutic use
Humans
Ligands
Microsomes -- enzymology
Models, Molecular
Protein Conformation
Sterols -- biosynthesis
Substrate Specificity
Trypanocidal Agents -- chemistry
Trypanocidal Agents -- metabolism
Trypanocidal Agents -- pharmacology
Trypanocidal Agents -- therapeutic use
Trypanosoma brucei brucei -- drug effects
Trypanosoma brucei brucei -- enzymology
Trypanosomiasis, African -- drug therapy
Note : Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:0021-9258 
info:doi/10.1074/jbc.M109.067470
info:pii/M109.067470
info:pmid/19923211