par Moser, Muriel 
Editeur scientifique Rose, N;Mackay, I
Référence The autoimmune diseases, Academic Press, page (37-46)
Publication Publié, 2006
Editeur scientifique Rose, N;Mackay, I
Référence The autoimmune diseases, Academic Press, page (37-46)
Publication Publié, 2006
Partie d'ouvrage collectif
| Résumé : | Dendritic cells (DCs) express several receptors that enable them to recognize self from non-self. At the immature stage, DCs exhibit potent endocytic activity: they constitutively macropinocytose extracellular fluids, and express various receptors specific for non-self-antigens. It is noteworthy that the maturation of DCs is often induced by microbial constituents and inflammatory cytokines, thereby favoring the activation of T cells specific for non-self-infectious antigens. They also display a unique phenotypic and functional maturation process, often associated with their migration. This specialization of function over time and location helps to focus the immune response on antigens likely to be delivered under inflammatory conditions. In addition to their immunostimulatory properties, DCs have the capacity to induce T-cell deletion and/or anergy, to trigger expansion of naturally occurring CD4+CD25+ regulatory T cells, and to activate the development of Tr1. These observations suggest that DCs favor immunity to non-self antigens by orchestrating the positive and negative regulation of immune responses. The mechanisms by which DCs display the opposite functions, i.e., induction of immunity and tolerance, are still not clear. © 2006 Elsevier Inc. All rights reserved. |
