Signal transduction in the human thyrocyte and its perversion in thyroid tumors.

Roger, Pierre P.; van Staveren, Wilma C G; Coulonval, Katia; Dumont, Jacques Emile; Maenhaut, Carine

doi:doi/10.1016/j.mce.2009.11.015

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Signal transduction in the human thyrocyte and its perversion in thyroid tumors.

par Roger, Pierre P.

;van Staveren, Wilma C G ;Coulonval, Katia

;Dumont, Jacques Emile

;Maenhaut, Carine

Référence Molecular and cellular endocrinology, 321, 1, page (3-19)
Publication Publié, 2010

Article révisé par les pairs

Résumé :

The study of normal signal transduction pathways regulating the proliferation and differentiation of a cell type allows to predict and to understand the perversions of these pathways which lead to tumorigenesis. In the case of the human thyroid cell, three cascades are mostly involved in tumorigenesis: The pathways and genetic events affecting them are described. Caveats in the use of models and the interpretation of results are formulated and the still pending questions are outlined.

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