Titre :
  • Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia.
Auteur : Coppola, Giovanni ; Marmolino, Daniele ; Lu, Daning ; Wang, Qinhong ; Cnop, Miriam ; Rai, Myriam ; Acquaviva, Fabio ; Cocozza, Sergio ; Pandolfo, Massimo ; Geschwind, Daniel H
Informations sur la publication : Human molecular genetics, 18, 13, (page 2452-2461)
Statut de publication : Publié, 2009
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Animals
Cells, Cultured
Friedreich Ataxia -- genetics
Friedreich Ataxia -- metabolism
Friedreich Ataxia -- therapy
Gene Expression Profiling
Gene Expression Regulation
Genomics
Humans
Insulin Resistance
Iron-Binding Proteins -- metabolism
Liver -- metabolism
Male
Mice
Mice, Knockout
Mice, Transgenic
Muscle, Skeletal -- metabolism
Myocardium -- metabolism
Oligonucleotide Array Sequence Analysis
Organ Specificity
PPAR gamma -- genetics
PPAR gamma -- metabolism
Signal Transduction
Note : Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0964-6906 
info:doi/10.1093/hmg/ddp183
info:pii/ddp183
info:pmid/19376812
info:pmcid/PMC2694693