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Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia.

par Coppola, Giovanni;Marmolino, Daniele ;Lu, Daning;Wang, Qinhong;Cnop, Miriam ;Rai, Myriam ;Acquaviva, Fabio;Cocozza, Sergio;Pandolfo, Massimo ;Geschwind, Daniel H
Référence Human molecular genetics, 18, 13, page (2452-2461)
Publication Publié, 2009

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Titre:	Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia.
Auteur:	Coppola, Giovanni; Marmolino, Daniele; Lu, Daning; Wang, Qinhong; Cnop, Miriam; Rai, Myriam; Acquaviva, Fabio; Cocozza, Sergio; Pandolfo, Massimo; Geschwind, Daniel H
Informations sur la publication:	Human molecular genetics, 18, 13, page (2452-2461)
Statut de publication:	Publié, 2009
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Animals
	Cells, Cultured
	Friedreich Ataxia -- genetics
	Friedreich Ataxia -- metabolism
	Friedreich Ataxia -- therapy
	Gene Expression Profiling
	Gene Expression Regulation
	Genomics
	Humans
	Insulin Resistance
	Iron-Binding Proteins -- metabolism
	Liver -- metabolism
	Male
	Mice
	Mice, Knockout
	Mice, Transgenic
	Muscle, Skeletal -- metabolism
	Myocardium -- metabolism
	Oligonucleotide Array Sequence Analysis
	Organ Specificity
	PPAR gamma -- genetics
	PPAR gamma -- metabolism
	Signal Transduction
Note générale:	Journal Article
	Research Support, N.I.H., Extramural
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0964-6906
	info:doi/10.1093/hmg/ddp183
	info:pii/ddp183
	info:scp/67249133451
	info:pmid/19376812
	PMC2694693