Titre :
  • Pharmacoscintigraphic and pharmacokinetic evaluation on healthy human volunteers of sustained-release floating minitablets containing levodopa and carbidopa.
Auteur : Goole, Jonathan ; Van Gansbeke, Bernard ; Pilcer, Gabrielle ; Deleuze, Philippe ; Blocklet, Didier ; Goldman, Serge ; Pandolfo, Massimo ; Vanderbist, Francis ; Amighi, Karim
Informations sur la publication : International journal of pharmaceutics, 364, 1, (page 54-63)
Statut de publication : Publié, 2008-11
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Carbidopa
Clinical study
Floating
Gamma scintigraphy
Levodopa
Minitablets
Pharmacokinetics
Sustained-release
Mots-clés MeSH : Adult
Antiparkinson Agents -- administration & dosage
Antiparkinson Agents -- adverse effects
Antiparkinson Agents -- pharmacokinetics
Area Under Curve
Carbidopa -- administration & dosage
Carbidopa -- adverse effects
Carbidopa -- pharmacokinetics
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Cross-Over Studies
Delayed-Action Preparations
Drug Combinations
Female
Half-Life
Humans
Indium Radioisotopes -- diagnostic use
Isotope Labeling
Levodopa -- administration & dosage
Levodopa -- adverse effects
Levodopa -- pharmacokinetics
Male
Powders
Radionuclide Imaging
Tablets
Tissue Distribution
Young Adult
Note : Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0378-5173 
info:doi/10.1016/j.ijpharm.2008.08.016
info:pii/S0378-5173(08)00543-7
info:pmid/18778758