Titre :
  • HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model.
Auteur : Rai, Myriam ; Soragni, Elisabetta ; Jenssen, Kai ; Burnett, Ryan ; Herman, David ; Coppola, Giovanni ; Geschwind, Daniel H ; Gottesfeld, Joel M ; Pandolfo, Massimo
Informations sur la publication : PloS one, 3, 4, (page e1958)
Statut de publication : Publié, 2008
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Acetylation -- drug effects
Animals
Cerebellum -- drug effects
Cerebellum -- metabolism
Chromatin -- metabolism
Disease Models, Animal
Enzyme Inhibitors -- pharmacology
Enzyme Inhibitors -- therapeutic use
Epigenesis, Genetic -- drug effects
Friedreich Ataxia -- drug therapy
Gene Expression Profiling
Histone Deacetylase Inhibitors
Histones -- metabolism
Introns -- genetics
Iron-Binding Proteins -- genetics
Iron-Binding Proteins -- metabolism
Mice
Myocardium -- metabolism
Protein Processing, Post-Translational -- drug effects
RNA, Messenger -- genetics
RNA, Messenger -- metabolism
Note : Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:1932-6203 
info:doi/10.1371/journal.pone.0001958
info:pmid/18463734
info:pmcid/PMC2373517