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The adjuvant OM-174 induces both the migration and maturation of murine dendritic cells in vivo.

par Pajak, Bernard ;Garze, Virginie ;Davies, G;Bauer, J;Moser, Muriel ;Chiavaroli, Carlo
Référence Vaccine, 21, 9-10, page (836-842)
Publication Publié, 2003-02

Article révisé par les pairs

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Résumé :

The aim of this study was to test the capacity of the novel adjuvant OM-174, a lipid A analog, to induce the migration and the maturation of murine dendritic cells (DC) in vivo, a step which is considered as the initiation of the adaptive immune response. BALB/c mice were injected intravenously or subcutaneously with OM-174. The spleen and popliteal lymph nodes were harvested, and analyzed for DC localization and phenotype. The data presented here clearly show that, OM-174 induces the migration of DC from the periphery to the T cell areas of lymphoid organs, and their maturation into cells expressing high levels of MHC class II and co-stimulatory molecules, with a potency close to that of Escherichia coli lipopolysaccharide (LPS).