par Goossens, D;Villafuerte, S;Tissir, F.;Van Gestel, Sofie;Claes, Stephan;Souery, Daniel ;Massat, Isabelle ;Van den Bossche, D;Van Zand, K;Mendlewicz, Julien ;Van Broeckhoven, Christine;Del-Favero, Jurgen
Référence European journal of human genetics, 8, 5, page (385-388)
Publication Publié, 2000-05
Référence European journal of human genetics, 8, 5, page (385-388)
Publication Publié, 2000-05
Article révisé par les pairs
Résumé : | We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed. |