Titre :
  • 2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity.
Auteur : Van Quaquebeke, Eric ; Mahieu, Tina ; Dumont, Patrick P. ; Dewelle, Janique ; Ribaucour, Fabrice ; Simon, Gentiane ; Sauvage, Sébastien ; Gaussin, Jean-François ; Tuti, Jérôme ; El Yazidi, Mohamed ; Van Vynckt, Frank ; Mijatovic, Tatjana ; Lefranc, Florence ; Darro, Francis ; Kiss, Robert
Informations sur la publication : Journal of medicinal chemistry, 50, 17, (page 4122-4134)
Statut de publication : Publié, 2007-08
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Acetamides -- chemical synthesis
Acetamides -- pharmacology
Acetamides -- toxicity
Animals
Antineoplastic Agents -- chemical synthesis
Antineoplastic Agents -- pharmacology
Antineoplastic Agents -- toxicity
Apoptosis
Autophagy
Camptothecin -- analogs & derivatives
Camptothecin -- pharmacology
Cell Aging
Cell Line, Tumor
DNA Topoisomerases, Type I -- antagonists & inhibitors
Deoxycytidine -- analogs & derivatives
Deoxycytidine -- pharmacology
Drug Screening Assays, Antitumor
Erythrocyte Count
Female
Humans
Imides -- pharmacology
Imides -- toxicity
Isoquinolines -- chemical synthesis
Isoquinolines -- pharmacology
Isoquinolines -- toxicity
Leukocyte Count
Maximum Tolerated Dose
Mice
Naphthalimides -- chemical synthesis
Naphthalimides -- pharmacology
Naphthalimides -- toxicity
Neoplasm Transplantation
Platelet Count
Structure-Activity Relationship
Urea -- analogs & derivatives
Urea -- chemical synthesis
Urea -- pharmacology
Urea -- toxicity
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0022-2623 
info:doi/10.1021/jm070315q
info:pmid/17658777