Non-classical pathways of cell-mediated allograft rejection: new challenges for tolerance induction?

Le Moine, Alain; Goldman, Michel

doi:doi/10.1034/j.1600-6143.2002.00026.x

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Non-classical pathways of cell-mediated allograft rejection: new challenges for tolerance induction?

par Le Moine, Alain

;Goldman, Michel

Référence American Journal of Transplantation, 3, 2, page (101-106)
Publication Publié, 2003-02

Article révisé par les pairs

Résumé :

Allograft rejection results from separate pathways primarily controlled by CD4+ T cells. Refinement of transplantation models together with investigations on rejection occurring despite co-stimulation blockade revealed unexpected pathways involving CD8+ T cells, NK cells and Th2 cytokines. In this minireview, we discuss these non-classical pathways of allograft rejection and their relevance for the induction of tolerance in the clinics.

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