Titre:
  • Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways.
Auteur:Dogusan, Zeynep; García, Mónica; Flamez, Daisy; Alexopoulou, Lena; Goldman, Michel; Gysemans, Conny; Mathieu, Chantal; Libert, Claude; Eizirik, Decio L.; Rasschaert, Joanne
Informations sur la publication:Diabetes, 57, 5, page (1236-1245)
Statut de publication:Publié, 2008
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Animals
Cell Survival
Cells, Cultured
Insulin-Secreting Cells -- cytology
Insulin-Secreting Cells -- physiology
Interferon Regulatory Factor-3 -- physiology
Interferon-beta -- biosynthesis
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Poly I-C -- pharmacology
RNA, Double-Stranded -- genetics
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Toll-Like Receptor 3 -- deficiency
Toll-Like Receptor 3 -- genetics
Toll-Like Receptor 3 -- physiology
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0012-1797
info:doi/10.2337/db07-0844
info:pii/db07-0844
info:scp/48449098774
info:pmid/18223009