par Eddahri, Fouad 
;Oldenhove, Guillaume ;Denanglaire, Sébastien ;Urbain, Jacques ;Leo, Oberdan ;Andris, Fabienne
Référence European Journal of Immunology, 36, 4, page (855-863)
Publication Publié, 2006-04
;Oldenhove, Guillaume ;Denanglaire, Sébastien ;Urbain, Jacques ;Leo, Oberdan ;Andris, Fabienne Référence European Journal of Immunology, 36, 4, page (855-863)
Publication Publié, 2006-04
Article révisé par les pairs
| Résumé : | CD4+ CD25+ T reg cells are critical for peripheral tolerance and prevention of autoimmunity. Here we show that CD4+ CD25+ T reg also regulate the magnitude of humoral responses against a panel of T-dependent antigens of foreign origin during both primary and secondary immune responses. Depletion of CD4+ CD25+ T cells leads to increased antigen-specific antibody production and affinity maturation but does not affect T-independent B cell responses, suggesting that CD4+ CD25+ T reg exert a feedback mechanism on non-self antigen-specific antibody secretion by dampening the T cell help for B cell activation. Moreover, we show that CD4+ CD25+ T reg also suppress in vitro B cell immunoglobulin production by inhibiting CD4+ CD25- T cell help delivery, and that blockade of TGF-beta activity abolishes this suppression. |
