par Malaisse, Willy 
;Doherty, Margaret;Mingrone, Geltrude;Ladrière, Laurence ;Greco, Alessandro
Référence Hormone and Metabolic Research, 33, 8, page (463-466)
Publication Publié, 2001-08
;Doherty, Margaret;Mingrone, Geltrude;Ladrière, Laurence ;Greco, AlessandroRéférence Hormone and Metabolic Research, 33, 8, page (463-466)
Publication Publié, 2001-08
Article révisé par les pairs
| Résumé : | In pancreatic islets from hereditarily diabetic GK rats, [1,12 -(14)C] dodecanedioic acid (5.0 mM) was oxidized at a rate representing about 5 % of that of D-[U - (14)C] glucose (8.3 mM). Dioic acid and hexose failed to exert any significant reciprocal effects on their respective oxidation. The production of (14)CO(2) from [1,12 -(14)C] dodecanedioic acid was proportional to its concentration in the 0.2 - 5.0 mM range. These results were essentially comparable to those obtained in islets from control rats. They extend, therefore, to GK rats the knowledge that dodecanedioic acid acts as a nutrient in pancreatic islet cells. |
