Titre :
  • Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.
Auteur : Andrade Da Cunha, Daniel ; Hekerman, Paul ; Ladrière, Laurence ; Bazarra-Castro, A. ; Ortis, Fernanda ; Wakeham, Marion ; Moore, Fabrice ; Rasschaert, Joanne ; Cardozo, Alessandra K ; Bellomo, Elisa ; Overbergh, Lutgart ; Mathieu, Chantal ; Lupi, R. ; Hai, Tsonwin ; Herchuelz, André ; Marchetti, Piero ; Rutter, Guy A ; Eizirik, Decio L. ; Cnop, Miriam
Informations sur la publication : Journal of cell science, 121, Pt 14, (page 2308-2318)
Statut de publication : Publié, 2008
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Apoptosis
Endoplasmic reticulum stress
Fatty acid
Islet
Lipotoxicity
Oleate
Palmitate
Pancreatic β-cell
Type 2 diabetes
Mots-clés MeSH : Activating Transcription Factor 3 -- metabolism
Activating Transcription Factor 6 -- metabolism
Animals
Apoptosis -- drug effects
Calcium -- metabolism
Endoplasmic Reticulum -- drug effects
Endoplasmic Reticulum -- enzymology
Endoplasmic Reticulum -- pathology
Fatty Acids, Nonesterified -- metabolism
Fatty Acids, Nonesterified -- toxicity
Glucose -- toxicity
Humans
Insulin-Secreting Cells -- drug effects
Insulin-Secreting Cells -- enzymology
Insulin-Secreting Cells -- pathology
JNK Mitogen-Activated Protein Kinases -- metabolism
Male
Membrane Proteins -- metabolism
Mice
Middle Aged
Protein-Serine-Threonine Kinases -- metabolism
Rats
Rats, Wistar
Signal Transduction -- drug effects
Transcription Factor CHOP -- metabolism
eIF-2 Kinase -- metabolism
Note : Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0021-9533 
info:doi/10.1242/jcs.026062
info:pii/jcs.026062
info:pmid/18559892