Titre:
  • Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.
Auteur:Gysemans, Conny A; Ladrière, Laurence; Callewaert, Hanne; Rasschaert, Joanne; Flamez, Daisy; Levy, David E; Matthys, Patrick; Eizirik, Decio L.; Mathieu, Chantal
Informations sur la publication:Diabetes, 54, 8, page (2396-2403)
Statut de publication:Publié, 2005
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Animals
Apoptosis
Cell Survival
Cytokines -- pharmacology
DNA-Binding Proteins -- deficiency
DNA-Binding Proteins -- physiology
Diabetes Mellitus, Experimental -- immunology
Female
Gene Expression -- drug effects
Insulin -- secretion
Interferon-gamma -- pharmacology
Interferon-gamma -- physiology
Interleukin-1 -- pharmacology
Islets of Langerhans -- cytology
Islets of Langerhans -- immunology
Male
Mice
Mice, Knockout
STAT1 Transcription Factor
Signal Transduction
Trans-Activators -- deficiency
Trans-Activators -- physiology
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0012-1797
info:pii/54/8/2396
info:pmid/16046307