Titre:
  • Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response.
Auteur:Lagneaux, Laurence; Gillet, Nicolas; Stamatopoulos, Basile; Delforge, Alain; Dejeneffe, Marielle; Massy, Martine; Meuleman, Nathalie; Kentos, Alain; Martiat, Philippe; Willems, Lucas; Bron, Dominique
Informations sur la publication:Experimental hematology, 35, 10, page (1527-1537)
Statut de publication:Publié, 2007-10
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Aged
Aged, 80 and over
Anticonvulsants -- pharmacology
Apoptosis -- drug effects
Apoptosis -- genetics
B-Lymphocytes -- metabolism
B-Lymphocytes -- pathology
CASP8 and FADD-Like Apoptosis Regulating Protein -- genetics
CASP8 and FADD-Like Apoptosis Regulating Protein -- metabolism
Caspase 8 -- genetics
Caspase 8 -- metabolism
DNA Fragmentation -- drug effects
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm -- drug effects
Drug Resistance, Neoplasm -- genetics
Drug Screening Assays, Antitumor
Enzyme Inhibitors -- pharmacology
Female
Gene Expression Regulation, Leukemic -- drug effects
Gene Expression Regulation, Leukemic -- genetics
Histone Deacetylase Inhibitors
Histone Deacetylases -- genetics
Humans
Immunoglobulin Heavy Chains -- genetics
Immunoglobulin Heavy Chains -- metabolism
Immunoglobulin Variable Region -- genetics
Immunoglobulin Variable Region -- metabolism
Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell -- genetics
Leukemia, Lymphocytic, Chronic, B-Cell -- metabolism
Leukemia, Lymphocytic, Chronic, B-Cell -- pathology
Male
Middle Aged
Mutation
Neoplasm Proteins -- genetics
Neoplasm Proteins -- metabolism
Phosphatidylserines -- metabolism
Signal Transduction -- drug effects
Signal Transduction -- genetics
TNF-Related Apoptosis-Inducing Ligand -- metabolism
Tumor Cells, Cultured
Valproic Acid -- pharmacology
Valproic Acid -- therapeutic use
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0301-472X
info:doi/10.1016/j.exphem.2007.06.014
info:pii/S0301-472X(07)00385-2
info:scp/34548703581
info:pmid/17697742