Titre:
  • Early induction of apoptosis in B-chronic lymphocytic leukaemia cells by hydroxychloroquine: activation of caspase-3 and no protection by survival factors
Auteur:Lagneaux, Laurence; Delforge, Alain; Carlier, Stefaan; Massy, M; Bernier, Michel; Bron, Dominique
Informations sur la publication:British journal of haematology, 112, 2, page (344-352)
Statut de publication:Publié, 2001-02
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Aged
Aged, 80 and over
Antirheumatic Agents -- therapeutic use
Apoptosis
Caspase 3
Caspases -- metabolism
Dose-Response Relationship, Drug
Enzyme Activation
Female
Humans
Hydroxychloroquine -- therapeutic use
Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell -- pathology
Male
Membrane Potentials
Middle Aged
Mitochondria -- metabolism
Proto-Oncogene Proteins c-bcl-2 -- metabolism
Tumor Cells, Cultured -- drug effects
Note générale:Journal Article
Research Support, Non-U.S. Gov't
FLWIN
Langue:Anglais
Identificateurs:urn:issn:0007-1048
info:doi/10.1046/j.1365-2141.2001.02553.x
info:pii/bjh2553
info:pmid/11167827