par Staquet, Maurice ;Bron, Dominique ;Rozencweig, Marcel ;Kenis, Y
Référence Journal of clinical pharmacology, 21, Supplément S1, page (60-63)
Publication Publié, 1981-09
Article révisé par les pairs
Résumé : BRL-4664, a THC analog, has been administered to 23 patients at a dose of 10 or 15 mg repeated twice. All patients were on cisplatin therapy, and 16 of them had experienced severe vomiting during the previous course of cisplatin. There was a statistically significant difference between the group with prior cisplatin therapy and without prior therapy in terms of number of vomiting episodes, emphasizing the role of conditioned reflexes. The dose of 15 mg administered before and twice after the infusion of cisplatin was well tolerated. Only minor side effects were observed.