Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.
par Killick, R;Scales, Georgie;Leroy, Karelle 
;Causevic, Mirsada;Hooper, Claudie;Irvine, Elaine E;Choudhury, Agharul I;Drinkwater, Laura;Kerr, Fiona;Al-Qassab, Hind;Stephenson, John;Yilmaz, Zehra ;Giese, K Peter;Brion, Jean Pierre ;Withers, Dominic J;Lovestone, S
Référence Biochemical and biophysical research communications, 386, 1, page (257-262)
Publication Publié, 2009-08
;Causevic, Mirsada;Hooper, Claudie;Irvine, Elaine E;Choudhury, Agharul I;Drinkwater, Laura;Kerr, Fiona;Al-Qassab, Hind;Stephenson, John;Yilmaz, Zehra ;Giese, K Peter;Brion, Jean Pierre ;Withers, Dominic J;Lovestone, SRéférence Biochemical and biophysical research communications, 386, 1, page (257-262)
Publication Publié, 2009-08
Article révisé par les pairs
| Titre: |
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| Auteur: | Killick, R; Scales, Georgie; Leroy, Karelle; Causevic, Mirsada; Hooper, Claudie; Irvine, Elaine E; Choudhury, Agharul I; Drinkwater, Laura; Kerr, Fiona; Al-Qassab, Hind; Stephenson, John; Yilmaz, Zehra; Giese, K Peter; Brion, Jean Pierre; Withers, Dominic J; Lovestone, S |
| Informations sur la publication: | Biochemical and biophysical research communications, 386, 1, page (257-262) |
| Statut de publication: | Publié, 2009-08 |
| Sujet CREF: | Sciences bio-médicales et agricoles |
| Mots-clés: | Abeta |
| Alzheimer's disease | |
| APP | |
| Diabetes | |
| GSK-3 | |
| Insulin signalling | |
| Irs2 | |
| PP2a | |
| Tau | |
| Transthyretin | |
| MeSH keywords: | Alzheimer Disease -- metabolism |
| Alzheimer Disease -- psychology | |
| Amyloid beta-Protein -- metabolism | |
| Animals | |
| Gene Deletion | |
| Hippocampus -- metabolism | |
| Hippocampus -- physiopathology | |
| Insulin Receptor Substrate Proteins -- genetics | |
| Insulin Receptor Substrate Proteins -- metabolism | |
| Memory | |
| Mice | |
| Mice, Transgenic | |
| Phosphorylation | |
| tau Proteins -- metabolism | |
| Note générale: | Journal Article |
| Research Support, Non-U.S. Gov't | |
| Langue: | Anglais |
| Identificateurs: | urn:issn:0006-291X |
| info:doi/10.1016/j.bbrc.2009.06.032 | |
| info:pii/S0006-291X(09)01170-X | |
| info:scp/67649224051 | |
| info:pmid/19523444 | |
| PMC2726921 |
