Titre :
  • HTLV-I infection of WE17/10 CD4(+) cell line leads to progressive alteration of Ca(2+) influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD wich paves the way for malignant transformation
Auteur : Akl, Haidar ; Badran, Bassam ; Zein, N. E. ; Bex, Françoise ; Sotiriou, Christos ; Willard, Karen ; Burny, A. ; Martiat, Philippe
Informations sur la publication : Leukemia, 21, (page 788-796)
Statut de publication : Publié, 2007-02-08
Sujet CREF : Cancérologie
Mots-clés MeSH : Antigens, CD7 -- genetics
Antigens, CD7 -- physiology
Apoptosis
CD4-Positive T-Lymphocytes -- drug effects
CD4-Positive T-Lymphocytes -- immunology
CD4-Positive T-Lymphocytes -- pathology
Calcium Signaling -- physiology
Cell Line
Cell Transformation, Neoplastic
Flow Cytometry
Gene Expression Regulation, Viral
HTLV-I Infections -- physiopathology
Humans
Ionomycin -- pharmacology
Oncogene Protein v-akt -- genetics
Oncogene Protein v-akt -- physiology
RNA -- genetics
RNA -- isolation & purification
Reverse Transcriptase Polymerase Chain Reaction
bcl-Associated Death Protein -- genetics
bcl-Associated Death Protein -- physiology
Note : Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:0887-6924 
info:doi/10.1038/sj.leu.2404585
info:pii/2404585
info:pmid/17287851
ha-0001